Diseño Óptimo de Experimentos
Cálculo de Diseños Óptimos para la ecuación de Antoine
CompARE is a free online platform to help investigators to design randomized clinical trials with composite endpoint. Following features are available:
Clinical trial designs with composite endpoints
R package to calculate the required sample size in randomized clinical trials with composite endpoints. This package also includes functions to calculate the probability of observing the composite endpoint and the expected effect on the composite endpoint, among others.
This section is devoted to the Optimal Design of Experiments subject. From general algorithms for computing optimal designs in an iterative process to adaptations for gaining in efficiency (computing time) for particular cases, including Elfving’s method for c-optimality, optimal designs for very popular models, etc. Of course, the main advantage is that they will be avaliable for any user through Internet.
Design of phase III trials with long-term survival outcomes based on short-term binary results
Sample size and effect size calculations for survival endpoints based on mixture survival-by-response model